tailieunhanh - Báo cáo y học: "Airways Disease: Phenotyping Heterogeneity Using Measures of Airway Inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Airways Disease: Phenotyping Heterogeneity Using Measures of Airway Inflammation. | REVIEW ARTICLE Airways Disease Phenotyping Heterogeneity Using Measures of Airway Inflammation Salman Siddiqui MRCP and Christopher E. Brightling MRCP PhD Despite asthma and chronic obstructive pulmonary disease being widely regarded as heterogeneous diseases a consensus for an accurate system of classification has not been agreed. Recent studies have suggested that the recognition of subphenotypes of airway disease based on the pattern of airway inflammation may be particularly useful in increasing our understanding of the disease. The use of non-invasive markers of airway inflammation has suggested the presence of four distinct phenotypes eosinophilic neutrophilic mixed inflammatory and paucigranulocytic asthma. Recent studies suggest that these subgroups may differ in their etiology immunopathology and response to treatment. Importantly novel treatment approaches targeted at specific patterns of airway inflammation are emerging making an appreciation of subphenotypes particularly relevant. New developments in phenotyping inflammation and other facets of airway disease mean that we are entering an era where careful phenotyping will lead to targeted therapy. Key words asthma COPD eosinophil inflammation neutrophil Asthma and chronic obstructive pulmonary disease COPD are the commonest respiratory diseases managed by pulmonologists. The incidence of asthma and COPD continues to By 2020 COPD is expected to be the third largest cause of global mortality and currently accounts for of global disability-adjusted Exacerbations of airway disease particularly those that lead to hospital admissions result in considerable morbidity and mortality as well as an enormous economic burden within health care systems. Asthma and COPD are characterized by the presence of symptoms of cough wheeze and breathlessness with airflow obstruction and underlying airway inflammation. Traditionally they are distinguished by the presence of variable airflow obstruction .