tailieunhanh - Báo cáo y học: "Antigen and Memory CD8 T Cells: Were They Both Right"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antigen and Memory CD8 T Cells: Were They Both Right? | ORIGINAL ARTICLE Antigen and Memory CD8 T Cells Were They Both Right Slava Epelman MD PhD and Christopher H. Mody MD Picture yourself as a researcher in immunology. To begin your project you ask a question Do CD8 T cells require antigen to maintain a memory response This question is of prime importance to numerous medical fields. In chronologic order you digest the literature but unfortunately you hit a major stumbling block in the 1990s. The crux of the problem is that which so often happens in science two well-recognized capable groups emerge with diametrically opposed conclusions leaving you pondering which set of well-controlled data to believe. Fortunately years later a surprising group of articles sheds light on this mystery and subtly reconciles these two positions. Key words antigen CD8 cells central memory effector memory Cytotoxic CD8 T cells are important mediators of host defense and their role in protective immunity has recently been highlighted by concerns of possible widespread pandemic viral infections. Designing strategies to immunize and therefore protect vulnerable populations requires a thorough understanding of the complex factors involved in the generation of CD8 memory cells. However there has been considerable debate over the years about the nature of CD8 memory cells whether they truly exist and if so what signals if any keep them alive for such an extended period of time. Memory cells are small and long-lasting proliferating slowly to maintain the size of the memory 2 If memory cells were quiescent there would be no need to regulate them. Understanding the mechanisms involved in the propagation of CD8 T-cell memory is critical to numerous areas of research including virus-host interactions vaccine development autoimmune diseases and cancer immunology. With that the stage is set for the retelling of an interesting scientific debate that had its beginning in the early 1990s and its end in recent years. The debate was based on the .