tailieunhanh - The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside

In this paper, participants in the Translational Medicine task force of the World Wide Web Consortium’s Health Care and Life Sciences Interest Group (W3C HCLSIG) present the Translational Medicine Ontology (TMO) and the Translational Medicine Knowledge Base (TMKB). The TMKB consists of the TMO, mappings to other terminologies and ontologies, and data in RDF format spanning discovery research and drug development, which are of therapeutic relevance to clinical research and clinical practice. The TMO provides a foundation for types declared in Linking Open Drug Data (LODD) [21] and EHRs. The TMO captures core, high-level termi- nology to bridge existing open domain ontologies and provides a framework to relate and. | Luciano et al. Journal of Biomedical Semantics 2011 2 Suppl 2 S1 l ĩĩĩ ĩ iĩ http content 2 S2 S1 oix kio JOURNAL OF ỉC -- 110 biomedicAL semantics 1010010100001 1100110001011 PROCEEDINGS Open Access The Translational Medicine Ontology and Knowledge Base driving personalized medicine by bridging the gap between bench and bedside c I I Ir i n 11 2Rmcco A nrlQrccrin3 Iin R fr k iolrt tr4 Oli icir Rrirlcitiroirlcir5 Tim r l2rlz6 7 k RatinQW8 Judiiiic S Lucidio Dosse Aideissoi Colli Ddicneloi Oliviei Dodeiieidei IIIII Cldik Ciiiisuie K Deiiey Christopher Domdiew9 Thomas Gdmbet10 Lee Hdildid11 Anjd Jentzsch12 Vipul Kdshyap13 Petei Kos6 Julid Kozlovsky14 Timothy Lebo1 Scott M Mdishdll15 16 Jdmes P McCuskei1 Deboidh L McGuiiiess1 17 18 2 10 192021 Chimezie Ogbuji Elgdi Pichlei Robert L Poweis Eiic Piud hommedux Mdtthids Sdmwdld 22 6 23 24 25 26 Lyii Schiiml Petei J Toielldto Pdtiicid L Whetzel Jui Zhdo Susie Stepheis Michel Dumoitiei From Dio-Oitologies 2010 Semditic Applicdtiois ii Life Scieices Dostoi MA USA. 9-10 July 2010 Coiiespoideice jlucidio@. edu 1Reisseldei Polytechiic listitute Tioy NY USA 26Cdiletoi Uiiveisity OttdWd Cdiddd Abstract Background Tidisldtioidl mediciie iequiies the iitegidtioi of kiowledge usiig heteiogeieous ddtd fiom hedlth cdie to the life scieices. Heie we desciibe d colldboidtive effort to produce d prototype Tidisldtioidl Mediciie Kiowledge Ddse TMKD cdpdble of disweiiig questiois ieldtiig to cliiicdl practice did phdimdceuticdl diug discoveiy. Results We developed the Tidisldtioidl Mediciie Oitology TMO ds d uiifyiig oitology to iitegidte chemicdl geiomic did pioteomic ddtd with disedse tiedtmeit did electioiic hedlth iecoids. We demoistidte the use of Semditic Web technologies ii the iitegidtioi of pdtieit did biomedicdl ddtd did ievedl how such d kiowledge bdse cdi did physicidis ii piovidiig tdiloied pdtieit cdie did fdcilitdte the ieciuitmeit of pdtieits iito dctive cliiicdl tiidls. .