tailieunhanh - báo cáo hóa học:" Anabolic steroids after total knee arthroplasty. A double blinded prospective pilot study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Anabolic steroids after total knee arthroplasty. A double blinded prospective pilot study | Hohmann et al. Journal of Orthopaedic Surgery and Research 2010 5 93 http content 5 1 93 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH RESEARCH ARTICLE Open Access Anabolic steroids after total knee arthroplasty. A double blinded prospective pilot study Erik Hohmann1 Kevin Tetsworth2 Stefanie Hohmann1 Adam L Bryant3 Abstract Background Total knee arthroplasty is reported to improve the patient s quality of life and mobility. However loss of mobility and pain prior to surgery often results in disuse atrophy of muscle. As a consequence the baseline functional state prior to surgery may result in poorer outcome post surgery and extended rehabilitation may be required. The use of anabolic steroids for performance enhancement and to influence muscle mass is well established. The positive effects of such treatment on bone and muscle could therefore be beneficial in the rehabilitation of elderly patients. The purpose of this study was to investigate the effects of small doses of Nandrolone decanoate on recovery and muscle strength after total knee replacement and to establish the safety of this drug in multimorbid patients. Methods This study was designed as a prospective double blind randomized investigation. Five patients treatment group with a mean age of 58-72 average BMI of received 50 mg nandrolone decanoate intramuscular bi-weekly for 6 months. The control group five patients mean age range 59-72 average BMI range was injected with saline solution. Pre-operatively and post-operatively 6 weeks 3 6 9 and 12 months all patients were assessed using the knee society score KSS isokinetic strength testing and functional tests a sit-to-stand and timed walking tests . In addition a bone density scan was used preoperatively and 6 month postoperatively to assess bone mineral density. Results Whilst the steroid group generally performed better than the placebo group for all of the functional tests ANOVA failed to .