tailieunhanh - báo cáo hóa học:" Augmentation of osteochondral repair with hyperbaric oxygenation: a rabbit study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Augmentation of osteochondral repair with hyperbaric oxygenation: a rabbit study | Chen et al. Journal of Orthopaedic Surgery and Research 2010 5 91 http content 5 1 91 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH RESEARCH ARTICLE Open Access Augmentation of osteochondral repair with hyperbaric oxygenation a rabbit study Alvin Chao-Yu Chen1 Mel S Lee1 Song-Shu Lin1 Leou-Chuan Pan2 Steve Wen-Neng Ueng3 Abstract Background Current treatments for osteochondral injuries often result in suboptimal healing. We hypothesized that the combination of hyperbaric oxygen HBO and fibrin would be superior to either method alone in treating full-thickness osteochondral defects. Methods Osteochondral repair was evaluated in 4 treatment groups control fibrin HBO and HBO fibrin groups at 2-12 weeks after surgical injury. Forty adult male New Zealand white rabbits underwent arthrotomy and osteochondral surgery on both knees. Two osteochondral defects were created in each femoral condyle one in a weight-bearing area and the other in a non-weight-bearing area. An exogenous fibrin clot was placed in each defect in the right knee. Left knee defects were left empty. Half of the rabbits then underwent hyperbaric oxygen therapy. The defects in the 4 treatment groups were then examined histologically at 2 4 6 8 and 12 weeks after surgery. Results The HBO fibrin group showed more rapid and more uniform repair than the control and fibrin only groups but was not significantly different from the group receiving HBO alone. In the 2 HBO groups organized repair and good integration with adjacent cartilage were seen at 8 weeks complete regeneration was observed at 12 weeks. Conclusions HBO significantly accelerated the repair of osteochondral defects in this rabbit model however the addition of fibrin produced no further improvement. Background Successful repair of full-thickness defects in articular cartilage has been a difficult goal to achieve. Spontaneous repair often fails to completely fill the defect and the new tissue is composed of fibrocartilage rather