tailieunhanh - Báo cáo y học: " A Novel Population of Mesenchymal Progenitors with Hematopoietic Potential Originated from CD14- Peripheral Blood Mononuclear Cell"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: A Novel Population of Mesenchymal Progenitors with Hematopoietic Potential Originated from CD14- Peripheral Blood Mononuclear Cells. | Int. J. Med. Sci. 2011 8 16 International Journal of Medical Sciences 2011 8 1 16-29 Ivyspring International Publisher. All rights reserved. Research Paper A Novel Population of Mesenchymal Progenitors with Hematopoietic Potential Originated from CD14- Peripheral Blood Mononuclear Cells Gang Hu1 2 x Peng Liu2 3 4 Jie Feng1 Yan Jin2 3 x 1. Department of Dermatology Second Hospital of Xi an Jiaotong University Xi an 710004 China 2. Research and Development Center for Tissue Engineering Fourth Military Medical University Xi an 710032 China 3. Department of Oral Histology and Pathology School of Stomatology Fourth Military Medical University Xi an 710032 China 4. Department of Stomatology Military Hospital of PLA Liaoyang 111000 China These authors contribute equally to the manuscript x Corresponding author Gang Hu . Department of Dermatology Second Hospital of Xi an Jiaotong University Xi an 710004 china Tel. 86-29-8767-9969 Fax 86-29-8740-9503 E-mail address gang1008@. Yan Jin PhD. Prof. Research and Development Center for Tissue Engineering Fourth Military Medical University Xi an 710032 China Tel. 86-29-8477-6147 Fax 86-29-8321-8039 E-mail address yanjin@. Received Accepted Published Abstract Hemopoietic system derived progenitor cells with mesenchymal features have been identified including CD14 monocyte-derived progenitors. However it is unclear whether there are mesenchyme derived progenitors with hematopoietic potential. Herein we identified a novel CD14- cell-derived population with both mesenchymal and hematopoietic features in rat peripheral blood and this cell population is different from the CD14 monocyte-derived progenitors but designated peripheral blood multipotential mesenchymal progenitors PBMMPs . Phenotype analysis demonstrated expression of mesenchymal markers in PBMMPs including BMPRs Endoglin CD105 Fibronectin Fn Vimentin Vim Collagen Col I II III along with hematopoietic marker .