tailieunhanh - báo cáo hóa học:" Mimivirus relatives in the Sargasso sea"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Mimivirus relatives in the Sargasso sea | Virology Journal BioMed Central Research Mimivirus relatives in the Sargasso sea Elodie Ghedin1 2 and Jean-Michel Claverie 3 Open Access Address department of Parasite and Virus Genomics The Institute for Genomic Research 9712 Medical Center Drive Rockville MD 20850 USA 2 Department of Microbiology and Tropical Medicine George Washington University Washington DC USA and 3Structural and Genomics Information laboratory CNRS-UPR2589 IBSM 13402 Marseille France University of Mediterranee School of Medicine 13385 Marseille France Email Elodie Ghedin - eghedin@ Jean-Michel Claverie - Corresponding author Published 16 August 2005 Received 01 May 2005 Accepted 16 August 2005 Virology Journal 2005 2 62 doi 186 1743-422X-2-62 This article is available from http content 2 1 62 2005 Ghedin and Claverie licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The discovery and genome analysis of Acanthamoeba polyphaga Mimivirus the largest known DNA virus challenged much of the accepted dogma regarding viruses. Its particle size 400 nm genome length million bp and huge gene repertoire 91 1 protein coding genes all contribute to blur the established boundaries between viruses and the smallest parasitic cellular organisms. Phylogenetic analyses also suggested that the Mimivirus lineage could have emerged prior to the individualization of cellular organisms from the three established domains triggering a debate that can only be resolved by generating and analyzing more data. The next step is then to seek some evidence that Mimivirus is not the only representative of its kind and determine where to look for new Mimiviridae. An exhaustive similarity search of all .