tailieunhanh - Báo cáo y học: "Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats. | Int. J. Med. Sci. 2010 7 232 International Journal of Medical Sciences 2010 7 4 232-239 Ivyspring International Publisher. All rights reserved Research Paper Influence of Cyclodextrin Complexation with NSAIDs on NSAID Cold Stress-Induced Gastric Ulceration in Rats Ibrahim A. Alsarra1 2 H Mahrous O. Ahmed1 Fars K. Alanazi1 3 Kamal Eldin Hussein ElTahir4 Abdulmalik M. Alsheikh5 and Steven H. Neau6 1. Department of Pharmaceutics College of Pharmacy King Saud University . Box 2457 Riyadh 11451 Saudi Arabia 2. Center of Excellence in Biotechnology Research King Saud University . Box 2460 Riyadh 11451 Saudi Arabia 3. Kayyali Chair for Pharmaceutical Industry College of Pharmacy King Saud University . Box 2457 Riyadh 11451 Saudi Arabia 4. Department of Pharmacology College of Pharmacy King Saud University . Box 2457 Riyadh 11451 Saudi Arabia 5. Department of Pathology Faculty of Medicine King Saud University . Box 2925 Riyadh 11461 Saudi Arabia 6. Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences in Philadelphia 600 South 43rd Street Philadelphia PA 19104 USA H Corresponding author Dr. Ibrahim A. Alsarra Phone 966 -1-4677504 Fax 966 -1-4676363 E-mail ialsar-ra@ Received Accepted Published Abstract The aim of this work was to study the ability of P-cyclodextrin P-CD or hydroxypropyl P-cyclodextrin HP-P-CD to ameliorate the induction of gastric ulcers by a nonsteroidal anti-inflammatory drug indomethacin or piroxicam in rats exposed to restraint and hypothermic stress at 4 C. Using oral gavage rats fasted for 72 h were administered the equivalent of a 100 mg kg dose of the assigned drug alone or with the designated cyclodextrin CD . The rats were placed in suitable rodent restrainers and then placed inside a ventilated refrigerator maintained at a temperature of 4 C. Six hours later each animal was removed anaesthetized with ether and the abdomen opened. Each stomach .