tailieunhanh - Báo cáo y học: "Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics. | Int. J. Med. Sci. 2010 7 136 International Journal of Medical Sciences 2010 7 3 136-146 Ivyspring International Publisher. All rights reserved Research Paper Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate A new chance in cancer diagnostics Klaus Braun1 H Lothar Dunsch2 Ruediger Pipkorn3 Michael Bock1 Tobias Baeuerle1 Shangfeng Yang2 4 Waldemar Waldeck5 and Manfred Wiessler1 1. Department of Medical Physics in Radiology German Cancer Research Center INF 280 D-69120 Heidelberg Germany 2. Department of Electrochemistry and conducting Polymers Leibniz-Institute for Solid State and Materials Research Helmholtzstrafie 20 D-01069 Dresden Germany 3. Core Facility Peptide Synthesis German Cancer Research Center INF 580 D-69120 Heidelberg Germany 4. Hefei National Laboratory for Physical Sciences at Microscale Department of Materials Science and Engineering Hefei 230026 China 5. Biophysics of Macromolecules German Cancer Research Center INF 580 D-69120 Heidelberg Germany H Corresponding author Dr. Klaus Braun Im Neuenheimer Feld 280 German Cancer Research Center Dep. Of Medical Physics in Radiology D-69120 Heidelberg Germany. Tel. No. 49 6221 42 2495 Fax No. 49 6221 42 3326 E-mail . de Received Accepted Published Abstract Among the applications of fullerene technology in health sciences the expanding field of magnetic resonance imaging MRI of molecular processes is most challenging. Here we present the synthesis and application of a GdxSc3-xN@C80-BioShuttle-conjugate referred to as Gd-cluster@-BioShuttle which features high proton relaxation and in comparison to the commonly used contrast agents high signal enhancement at very low Gd concentrations. This modularly designed contrast agent represents a new tool for improved monitoring and evaluation of interventions at the gene transcription level. Also a widespread monitoring to track individual cells