tailieunhanh - báo cáo hóa học:" Ultrastructural studies on dengue virus type 2 infection of cultured human monocytes"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Ultrastructural studies on dengue virus type 2 infection of cultured human monocytes | Virology Journal BioMed Central Research Open Access Ultrastructural studies on dengue virus type 2 infection of cultured human monocytes Jesus A Mosquera 1 Juan Pablo Hernandez2 Nereida Valero3 Luz Marina Espina3 and German J Anez3 Address 1Seccion de Inmunologia y Biologia Celular Instituto de Investigaciones Clinicas Dr. Americo Negrette . Facultad de Medicina Universidad del Zulia Maracaibo Venezuela 2Instituto de Investigaciones Biologicas. Facultad de Medicina Universidad del Zulia Maracaibo Venezuela and 3Seccion de Virologia Instituto de Investigaciones Clinicas Dr. Americo Negrette . Facultad de Medicina Universidad del Zulia Maracaibo Venezuela Email Jesus A Mosquera - mosquera99ve@ Juan Pablo Hernandez - asisca_jph@ Nereida Valero - nere98@ Luz Marina Espina - lmespina@ German J Anez - ganezg@ Corresponding author Published 31 March 2005 Received 05 March 2005 Accepted 31 March 2005 Virology Journal 2005 2 26 doi l743-422X-2-26 This article is available from http content 2 1 26 2005 Mosquera et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Early interaction of dengue virus and monocyte macrophages could be an important feature for virus dissemination after its initial entry via the mosquito vector. Since ultrastructural analysis of this interaction has not been reported dengue type 2 DEN2 virus-infected human monocyte cultures were studied at 1 2 4 and 6 hours after infection. Results Typical dengue particles and fuzzy coated viral particles were 35 to 42 nm and 74 to 85 nm respectively. Viruses were engulfed by phagocytosis and macropicnocytosis leading to huge vacuoles and phagosomes inside the monocytes. .