tailieunhanh - Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatment. | Int. J. Med. Sci. 2010 7 36 International Journal of Medical Sciences 2010 7 1 36-42 Ivyspring International Publisher. All rights reserved Research Paper Weight loss leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatment Nuntra Suwantarat Alan D. TiceH Thana Khawcharoenporn Dominic C. Chow Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu Hawaii USA 96813. H Corresponding Author Alan D. Tice MD FACP. Infections Limited Hawaii 1286 Queen Emma Street Honolulu Hawaii 96813. E-mail alantice@ Telephone 1-808-373-3488 Fax 1-808-536-2024. Co-Corresponding Author Nuntra Suwantarat MD. Department of Medicine John A. Burns School of Medicine University of Hawaii 1356 Lusitana Street 7th Floor Honolulu HI 96813. E-mail nuntra@ Telephone 1-808- 586-2910 Fax 1-808-586-7486 Received Accepted Published Abstract OBJECTIVE To identify apparent adverse effects of treatment of chronic hepatitis C and their relationship to sustained virologic response SVR . METHODS A retrospective study was conducted of all Hepatitis C virus HCV -infected patients treated with pegylated interferon and ribavirin in an academic ambulatory infectious disease practice. Clinical and laboratory characteristics were compared between patients with SvR and without SVR. RESULTS Fifty-four patients completed therapy with the overall SVR rate of 76 . SVR was associated with genotype non-1 P weight loss more than 5 kilograms P end of treatment leukopenia P and thrombocytopenia P . In multivariate analysis SVR was significant associated with HCV genotype non-1 Adjusted Odd Ratio AOR CI to P weight loss more than 5 kilograms AOR CI to P and end of treatment white blood cell count level less than 3 X 103 cells pl AOR CI to P . Thrombocytopenia was not significant after adjustment. Other factors .