tailieunhanh - Báo cáo y học: "The Diels-Alder-Reaction with inverse-Electron-Demand, a very efficient versatile Click-Reaction Concept for proper Ligation of variable molecular Partners"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: The Diels-Alder-Reaction with inverse-Electron-Demand, a very efficient versatile Click-Reaction Concept for proper Ligation of variable molecular Partners. | Int. J. Med. Sci. 2010 7 19 International Journal of Medical Sciences 2010 7 1 19-28 Ivyspring International Publisher. All rights reserved Research Paper The Diels-Alder-Reaction with inverse-Electron-Demand a very efficient versatile Click-Reaction Concept for proper Ligation of variable molecular Partners Manfred Wiessler1 Waldemar Waldeck2 Christian Kliem1 Ruediger Pipkorn3 and Klaus Braun 1 H 1. German Cancer Research Center Dept. of Imaging and Radiooncology INF 280 D-69120 Heidelberg Germany 2. German Cancer Research Center Division of Biophysics of Macromolecules INF 580 D-69120 Heidelberg Germany 3. German Cancer Research Center Central Peptide Synthesis Unit INF 580 D-69120 Heidelberg Germany ISI Correspondence to Dr. Klaus Braun German Cancer Research Center DKFZ Dept. of Imaging and Radiooncology Im Neuenhemer Feld 280 D-69120 Heidelberg Germany. Tel 49 6221 42 2495 Fax 49 6221 42 3326. Received Accepted Published Abstract The ligation of active pharmaceutical ingredients API for working with image processing systems in diagnostics MRT attracts increasing notice and scientific interest. The Diels-Alder ligation Reaction with inverse electron demand DARinv turns out to be an appropriate candidate. The DARinv is characterized by a specific distribution of electrons of the diene and the corresponding dienophile counterpart. Whereas the reactants in the classical Diels-Alder Reaction feature electron-rich diene and electron-poor dienophile compounds the DARinv exhibits exactly the opposite distribution of electrons. Substituents with pushing electrones increase and with pulling electrons reduce the electron density of the dienes as used in the DARinv. We report here that the DARinv is an efficient route for coupling of multifunctional molecules like active peptides re-formulated drugs or small molecules like the alkyalting agent temozolomide TMZ . This is an example of our contribution to the Click chemistry

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.