tailieunhanh - Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1. | Int. J. Med. Sci. 2011 8 161 Short Research Communication International Journal of Medical Sciences 2011 8 2 161-167 Ivyspring International Publisher. All rights reserved. Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1 Wanpeng Sun1 Ling Qiao2 Qiang Liu2 Lifeng Chen1 Binbing Ling1 Ramaswami Sammynaiken3 and Jian Yang1 x 1. Drug Design and Discovery Research Group College of Pharmacy and Nutrition University of Saskatchewan 110 Science Place Saskatoon SK S7N 5C9 Canada 2. Vaccine and Infectious Disease Organization University of Saskatchewan 120 Veterinary Road Saskatoon SK S7N 5E3 Canada 3. Saskatchewan Structural Sciences Centre University of Saskatchewan 110 Science Place Saskatoon SK S7N 5C9 Canada H Corresponding author Jian Yang Drug Design and Discovery Research Group College of Pharmacy and Nutrition University of Saskatchewan 110 Science Place Saskatoon SK S7N 5C9 Canada. Tel 306-966-6361 Fax 306-966-6377 E-mail jian. yang@usask. ca Received Accepted Published Abstract Human tumor suppressor gene RIZ encodes two protein products tumor suppressor RIZ1 and proto-oncoprotein RIZ2 which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer stage III for prostate cancer indicating that RIZ1 might play an important role in tumor metastasis and the PR domain alone possessed anticancer activity. Key words RIZ1 RIZ Human tumor suppressor tumor metastasis Introduction Yin-Yang regulation which refers to dual complimentary opposite reactions has been discovered in many biological and physiological regulations. Recently human tumor suppressor gene RIZ was shown to function in a Yin-Yang fashion 1 2 . RIZ located on the distal short arm of chromosome 1 1p36 encodes two different protein products RIZ1 and RIZ2 using .