tailieunhanh - Báo cáo y học: "Relationship between Anti-CCP Antibodies and Oxidant and Anti-Oxidant Activity in Patients with Rheumatoid Arthrit"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Relationship between Anti-CCP Antibodies and Oxidant and Anti-Oxidant Activity in Patients with Rheumatoid Arthritis. | Int. J. Med. Sci. 2011 8 139 International Journal of Medical Sciences 2011 8 2 139-147 Ivyspring International Publisher. All rights reserved. Research Paper Relationship between Anti-CCP Antibodies and Oxidant and Anti-Oxidant Activity in Patients with Rheumatoid Arthritis Levent Ediz1H Ozcan Hiz1 Halil Ozkol2 Elif Gulcu1 Murat Toprak1 Mehmet Fethi Ceylan3 1. Yuzuncu Yil University Medical Faculty Department of Physical Medicine Rehabilitation and Rheumatology Van Turkey 2. Yuzuncu Yil University Medical Faculty Department of Medical Biology Van Turkey 3. Yuzuncu Yil University Medical Faculty Department of Orthopaedics Van Turkey H Corresponding author Associate Professor Levent Ediz MD PhD. Yuzuncu Yil University Medical Faculty Department of Physical Medicine and Rehabilitation 65100 Van Turkey. Tel. 90 432 2150182 fax 90 432 2168352. E-mail address le-ventediz@ Received Accepted Published Abstract Objective Aim A new group of autoantibodies in Rheumatoid Arthritis RA the anti-cyclic citrullinated peptide anti-CCP antibodies directed to citrulline-containing proteins which are of value for the severity of RA. Up to date the relationship between anti-CCP antibodies and oxidant anti-oxidant activity in patients with RA has not been elucidated in the previous studies. In this study we aimed to investigate the effect of anti-CCP antibodies in the circulation on whole blood serum and synovial fluid oxidant and anti-oxidant activity in patients with RA. Materials and Methods RA patients with anti-CCP n 25 and anti-CCP - n 24 were recruited into the study. All patients had a positive rheumatoid factor RF . The patients who were under treatment with only non-steroidal antiinflammatory drugs NSAID at the study time included in the study. Catalase CAT Glutathione peroxidase GSHPx Myeloperoxidase MPO activities and the levels of Malondialdehyde MDA were measured in whole blood serum and synovial fluid in both groups. Results .