tailieunhanh - Báo cáo y học: "High Dose Astaxanthin Lowers Blood Pressure and Increases Insulin Sensitivity in Rats: Are These Effects Interdependen"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: High Dose Astaxanthin Lowers Blood Pressure and Increases Insulin Sensitivity in Rats: Are These Effects Interdependent?. | Int. J. Med. Sci. 2011 8 126 International Journal of Medical Sciences 2011 8 2 126-138 Ivyspring International Publisher. All rights reserved. Research Paper High Dose Astaxanthin Lowers Blood Pressure and Increases Insulin Sensitivity in Rats Are These Effects Interdependent Harry G. Preuss10 Bobby Echard1 Eiji Yamashita2 Nicholas V. Perricone3 1. Georgetown University Medical Center Department of Biochemistry Washington . 20057 USA 2. Life Science Division Fuji Chemical Industry Co. Ltd. Toyama 930-0397 Japan 3. Michigan State University College of Human Medicine East Lansing MI 48824-136 USA H Corresponding author Harry G. Preuss . . . Professor of Biochemistry Medicine Pathology Georgetown University Medical Center Basic Science Building Room 231 B 4000 Reservoir Road NW Washington . 20057. Work Phone 202-687-1441 Fax 202-687-8788 E mail preusshg@ Received Accepted Published Abstract The present investigation in Sprague-Dawley rats SD was designed to examine effects of astaxanthin Asta at different doses on elevated blood pressure BP and glucose-insulin perturbations produced by heavy sucrose ingestion. We also examined effects of Asta on BP during restraint stress. SD were divided into six groups each containing eight rats. All SD ate a basic diet of ground regular rat chow with sucrose added at 30 w w. The Control group received only the basic diet containing added sucrose while the other five groups each received the same diet with added test material captopril 30 mg Kg pioglitazone mg Kg low Asta 25 mg Kg medium Asta 50 mg kg or high Asta 100 mg Kg . Many tests were carried out to examine the mechanisms behind the effects of Asta on BP serum ACE activity losartan challenge and LNAME challenge and the glucose-insulin system glucose tolerance HOMA measurement and insulin challenge . In SD a relatively low dose of Asta decreased SBP but produced no major changes in the glucose-insulin .