tailieunhanh - Báo cáo y học: "Effects of Flurbiprofen on CRP, TNF-α, IL-6, and Postoperative Pain of Thoracotomy"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Effects of Flurbiprofen on CRP, TNF-α, IL-6, and Postoperative Pain of Thoracotomy. | Int. J. Med. Sci. 2011 8 216 International Journal of Medical Sciences 2011 8 3 216-221 Research Paper Effects of Flurbiprofen on CRP TNF-a IL-6 and Postoperative Pain of Thoracotomy Hidir Esme1 Recep Kesli2H Burhan Apiliogullari1 Ferdane Melike Duran1 Banu Yoldas1 1. Department of Thoracic Surgery Konya Education and Research Hospital Konya Turkey 2. Microbiology Laboratory Konya Education and Research Hospital Konya Turkey H Corresponding author Recep Kesli MD. Konya Education and Research Hospital Microbiology Laboratory Meram Yeni Yol 42090 Konya Turkey. E-mail recepkesli@ Phone 90 332 324 21 60 Fax 90 332 324 21 60. Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License http licenses by-nc-nd . Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. Received Accepted Published Abstract Objective The aims of this study were to evaluate serum levels of acute phase reactants such as CRP and cytokines TNF-a and IL-6 in patients who have undergone thoracotomy and to investigate the effects of flurbiprofen on postoperative inflammatory response. Methods Forty patients undergoing posterolateral thoracotomy were randomly divided into 2 groups of 20 each. Control group received tramadol 4 x 100 mg intravenously for four days and flurbiprofen group received both tramadol 4 x 100 mg and flurbiprofen 2 x 100 mg . Blood samples were collected before surgery and at the 3th and 168th hours after surgical procedure to measure serum CRP IL-6 and TNF-a. Pain visual analog scales were recorded daily during the first four postoperative days. Spirometric measurement of forced expiratory volume in the first second FEV 1 was done before and four days after the operation. Results The serum CRP IL-6 and TNF-a levels in both groups increased significantly at 3th hour after .