tailieunhanh - Báo cáo y học: "Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/ cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/ cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma. | Int. J. Med. Sci. 2009 6 305 International Journal of Medical Sciences 2009 6 6 305-311 Ivyspring International Publisher. All rights reserved Research Paper Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma Akiko Kuwahara 1 Motohiro Yamamori 2 Kohshi Nishiguchi 3 4 Tatsuya Okuno 3 Naoko Chayahara 3 Ikuya Miki 3 Takao Tamura 3 Tsubasa Inokuma 2 Yoshiji Takemoto 2 Tsutomu Nakamura 3 Kazusaburo Kataoka 1 and Toshiyuki Sakaeda 2 3 H 1. School of Pharmacy and Pharmaceutical Sciences Mukogawa Women s University Nishinomiya Japan 2. Graduate School of Pharmaceutical Sciences Kyoto University Kyoto Japan 3. Kobe University Graduate School of Medicine Kobe Japan 4. Faculty of Pharmaceutical Sciences Kyoto Pharmaceutical University Kyoto Japan ISI Correspondence to Toshiyuki Sakaeda . Center for Integrative Education of Pharmacy Frontier Frontier Education Center Graduate School of Pharmaceutical Sciences Kyoto University 46-29 Yoshidashimoadachi-cho Sakyo-ku Kyoto 606-8501 Japan. Tel 81-75-753-9560 Fax 81-75-753-4502 E-Mail sakaedat@ Received Accepted Published Abstract Objective The effects of replacing cisplatin CDDP with cis-diammineglycolatoplatinum nedaplatin NDP a second-generation platinum complex on the pharmacokinetics of 5-fluorouracil 5-FU were investigated in Japanese patients with esophageal squamous cell carcinoma who were treated with a definitive 5-FU CDDP-based chemoradiotherapy. Methods Fifty-six patients were enrolled 49 treated with CDDP and 7 treated with NDP. A course consisted of continuous infusion of 5-FU at 400 mg m2 day for days 1-5 and 8-12 infusion of CDDP or NDP at 40 mg m2 day on days 1 and 8 and radiation at 2 Gy day on days 1 to 5 8 to 12 and 15 to 19 with a second course repeated after a 2-week interval. Plasma concentrations of 5-FU were determined by high performance