tailieunhanh - Báo cáo y học: "Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits. | Int. J. Med. Sci. 2009 6 218 International Journal of Medical Sciences 2009 6 4 218-223 Ivyspring International Publisher. All rights reserved Research Paper Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits Emiko Kohno1 H Saori Murase2 Kenji Matsuyama3 Noboru Okamura2 1. Department of Hospital Pharmacy Kansai Medical University Takii Hospital 10-15 Fumizono-cho Moriguchi Osaka 570-8507 Japan 2. Department of Clinical Pharmacy School of Pharmaceutical Sciences Mukogawa Women s University 11-68 Koshien-Kyuban-cho Nishinomiya Hyogo 663-8179 Japan 3. Department of Clinical Pharmacy School of Pharmacy Kinki University 3-4-10 Kowakae Higashiosaka Osaka 577-8502 Japan H Correspondence to Emiko Kohno MS Vice Director Department of Pharmacy Kansai Medical University Takii Hospital 10-15 Fumizono-cho Moriguchi Osaka 570-8507 Japan. Tel 81-6-6992-1001 Fax 81-6-6995-5425 E-mail kohnoe@takii. kmu. Received Accepted Published Abstract Purpose Phlebitis caused by intravenous infusion of antineoplastic agents is one of the critical problems when anticancer therapy is prolonged. We have already reported that both rapid infusion and dilution of the injection solution were effective methods for reducing phlebitis caused by vinorelbine VNR in rabbits. The aim of this study was to explore other practical methods for preventing phlebitis caused by VNR and doxorubicin DXR in a rabbit model. VNR is often used with cisplatin and dexamethasone DEX has been co-administered for prevention of cisplatin-induced nausea. DXR is used with prednisolone PSL in the CHOP regimen for the treatment of non-Hodgkin s lymphoma. Therefore the present study investigated the prevention of phlebitis due to VNR with DEX and that due to DxR with pSl. Methods VNR and DXR were diluted with normal saline to prepare test solutions at concentrations of mg mL and mg mL respectively. Each test solution was infused .