tailieunhanh - báo cáo hóa học:" Establishment of an animal model of a pasteurized bone graft, with a preliminary analysis of muscle coverage or FGF-2 administration to the graft"

tạp chí sinh học quốc tế đề tài : Establishment of an animal model of a pasteurized bone graft, with a preliminary analysis of muscle coverage or FGF-2 administration to the graft | Journal of Orthopaedic Surgery and Research Research article BioMed Central Open Access Establishment of an animal model of a pasteurized bone graft with a preliminary analysis of muscle coverage or FGF-2 administration to the graft Tatsuya Yoshida Akio Sakamoto Nobuaki Tsukamoto Koichi Nakayama and Yukihide Iwamoto Address Department of Orthopaedic Surgery Graduate School of Medical Sciences Kyushu University Fukuoka Japan Email Tatsuya Yoshida - yoshidat@ Akio Sakamoto - akio@ Nobuaki Tsukamoto - nobtsuka@ Koichi Nakayama - koichi-n@ Yukihide Iwamoto - yiwamoto@ Corresponding author Published 4 August 2009 Received 22 December 2008 Journal of Orthopaedic Surgery and Research 2009 4 31 doi 1749-799X-4-3 1 Accepted 4 August 2009 This article is available from http content 4 1 31 2009 Yoshida et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Pasteurized bone grafting is used following the excision of a bone tumor for the purpose of eliminating neoplastic cells while preserving bone-inducing ability. In the hopes of guaranteeing the most favourable results the establishment of an animal model has been urgently awaited. In the course of establishing such a model we made a preliminary examination of the effect of muscle coverage or fibroblast growth factor 2 FGF-2 administration radiographically. Methods Forty pasteurized intercalary bone grafts of the Wistar rat femur treated at 60 C for 30 min were reimplanted and stabilized with an intramedullary nail mm in diameter . Some grafts were not covered by muscle after the implantation so that they could act as a .

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