tailieunhanh - Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease. | Int. J. Med. Sci. 2007 4 140 International Journal of Medical Sciences ISSN 1449-1907 2007 4 3 140-145 Ivyspring International Publisher. All rights reserved Research Paper BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease Teresa A. Evans1 Arun K. Raina1 André Delacourte2 Olga Aprelikova3 Hyoung-gon Lee1 Xiongwei Zhu1 George Perry1 4 Mark A. Smith1 1. Department of Pathology Case Western Reserve University Cleveland Ohio 44106 USA 2. Inserm U837 JPARC Bat. G. Biserte 1 place de Verdun 59045 Lille cedex France 3. Laboratory of Biosystems and Cancer National Cancer Institute NIH Bethesda Maryland 20892 USA 4. College of Sciences University of Texas at San Antonio San Antonio Texas 78249 USA Correspondence to Mark A. Smith . Department of Pathology Case Western Reserve University 2103 Cornell Road Cleveland Ohio 44106 USA. Tel 216-368-3670 Fax 216-368-8964 Received Accepted Published In Alzheimer disease neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary tangles contain the antigenic profile of many cell cycle markers reflecting a re-entry into the cell cycle by affected neurons. However while such a cell cycle re-entry phenotype is an early and consistent feature of Alzheimer disease the mechanisms responsible for neuronal cell cycle are unclear. In this regard given that a dysregulated cell cycle is a characteristic of cancer we speculated that alterations in oncogenic proteins may play a role in neurodegeneration. To this end in this study we examined brain tissue from cases of Alzheimer disease for the presence of BRCA1 a known regulator of cell cycle and found intense and specific localization of BRCA1 to neurofibrillary tangles a hallmark lesion of the disease. Analysis of clinically normal aged brain tissue revealed systematically less BRCA1 and surprisingly in many cases with apparent .