tailieunhanh - Báo cáo y học: "No increased risk of infant hypospadias after maternal use of loratadine in early pregnancy"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: No increased risk of infant hypospadias after maternal use of loratadine in early pregnancy. | Int. J. Med. Sci. 2006 3 106 Short research communication International Journal of Medical Sciences ISSN 1449-1907 2006 3 3 106-107 2006 Ivyspring International Publisher. All rights reserved No increased risk of infant hypospadias after maternal use of loratadine in early pregnancy Bengt Kallen Petra Otterblad Olausson Tornblad Institute University of Lund and Swedish National Board of Health and Welfare Stockholm Sweden Corresponding address Professor Bengt Kallen Tornblad Institute Biskopsgatan 7 SE-223 62 Lund Sweden. Received Accepted Published The original report published in 2001 on a possible association between maternal use of loratadine and an increased risk of infant hypospadias based on data in the Swedish Medical Birth Register 1995-2001 has been followed up by continued surveillance in the same register. The original signal was based on 15 infants with hypospadias among 2780 loratadine-exposed infants born representing an adjusted odd ratio of about statistically significant. Since then another 10 cases have been identified and expected. For the period 2001-2004 another 1911 loratadine-exposed infants have been identified and only two hadhypospadias 4 expected . Our present position is that the primary finding was a signal which had occurred by chance and the follow-up agrees with independent studies which indicate an absence of an association. This illustrates the care with which apparent statistically significant increases have to be handled when no prior hypothesis exists. Key words Hypospadias loratadine pregnancy drug safety. 1. Introduction In a recent issue of International Journal of Medical Sciences a study was published based on a prescription register in Denmark which indicated an absence of an association between maternal use of loratadine and an increased risk for hypospadias in the offspring 1 . The reason for that study was a report we wrote 2 which described a system for an .

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