tailieunhanh - Báo cáo y học: "Does Flavanol Intake Influence Mortality from Nitric Oxide-Dependent Processes"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Does Flavanol Intake Influence Mortality from Nitric Oxide-Dependent Processes? | Int. J. Med. Sci. 2007 4 53 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2007 4 1 53-58 Ivyspring International Publisher. All rights reserved Does Flavanol Intake Influence Mortality from Nitric Oxide-Dependent Processes Ischemic Heart Disease Stroke Diabetes Mellitus and Cancer in Panama Vicente Bayard 1 Fermina Chamorro 1 Jorge Motta 2 and Norman K. Hollenberg 3 1. Instituto Commemorative Gorgas de Estudios de la Salud and The Department of Preventive Medicine School of Medicine University of Panama Panama City PANAMA and Gorgas Institute Panama City PANAMA 2. Instituto Commemorative Gorgas de Estudios de la Salud Panama City PANAMA 3. Brigham and Women s Hospital and Harvard Medical School Boston Massachusetts USA. Correspondence to Norman K. Hollenberg . . Brigham and Women s Hospital 75 Francis Street Boston MA 02115. Tel 617 732-6682 Fax 617 232-2869 e-mail djpagecapo@ Received Accepted Published Substantial data suggest that flavonoid-rich food could help prevent cardiovascular disease and cancer. Cocoa is the richest source of flavonoids but current processing reduces the content substantially. The Kuna living in the San Blas drink a flavanol-rich cocoa as their main beverage contributing more than 900 mg day and thus probably have the most flavonoid-rich diet of any population We used diagnosis on death certificates to compare cause-specific death rates from year 2000 to 2004 in mainland and the San Blas islands where only Kuna live. Our hypothesis was that if the high flavanoid intake and consequent nitric oxide system activation were important the result would be a reduction in the frequency of ischemic heart disease stroke diabetes mellitus and cancer - all nitric oxide sensitive processes. There were 77 375 deaths in mainland Panama and 558 deaths in the San Blas. In mainland Panama as anticipated cardiovascular disease was the leading cause of death

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