tailieunhanh - Báo cáo y học: "The Natural History of Hepatitis C Virus (HCV) Infection"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: The Natural History of Hepatitis C Virus (HCV) Infection. | Int. J. Med. Sci. 2006 3 47 International Journal of Medical Sciences ISSN 1449-1907 2006 3 2 47-52 2006 Ivyspring International Publisher. All rights reserved Review The Natural History of Hepatitis C Virus HCV Infection Stephen L. Chen 1 2 and Timothy R. Morgan 1 2 1. Gastroenterology Section VA Medical Center Long Beach California 2. Division of Gastroenterology and Hepatology University of California-Irvine Irvine California Corresponding address Timothy R. Morgan MD VA Long Beach Healthcare System 5901 East Seventh Street Long Beach California 90822. E-mail . FAX 562 826-8023 Received Accepted Published Hepatitis C virus HCV is a leading cause of chronic liver disease cirrhosis and hepatocellular carcinoma as well as the most common indication for liver transplantation in many countries. Although the incidence of hepatitis C infection has dramatically decreased during the past decade the worldwide reservoir of chronically infected persons is estimated at 170 million or 3 of the global population. There is much controversy surrounding the natural history of hepatitis C infection. The rate of chronic HCV infection is affected by a person s age gender race and viral immune response. Approximately 75 -85 of HCV-infected persons will progress to chronic HCV infection and are at risk for the development of extrahepatic manifestations compensated and decompensated cirrhosis and hepatocellular carcinoma HCC . The rate of progression to cirrhosis is highly variable and is influenced by several factors including the amount of alcohol consumption age of initial HCV infection degree of inflammation and fibrosis on liver biopsy HIV and HBV coinfection and comordid conditions. An estimated 10 -15 of HCV-infected persons will advance to cirrhosis within the first 20 years. Persons with cirrhosis are at increased risk of developing HCC. An understanding of the natural history of hepatitis C is essential