tailieunhanh - Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease. | Int. J. Med. Sci. 2006 3 35 International Journal of Medical Sciences ISSN 1449-1907 2006 3 2 35-40 2006 Ivyspring International Publisher. All rights reserved Review Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCV-Related Liver Disease Stéphane Chevaliez Jean-Michel Pawlotsky Department of Virology INSERM U635 Henri Mondor Hospital University of Paris XII Créteil France Corresponding address Professor Jean-Michel PAWLOTSKY . . Department of Virology Hôpital Henri Mondor 51 avenue du Maréchal de Lattre de Tassigny 94010 Créteil France. Tel 33-1-4981-2827 Fax 33-1-4981-4831. E-mail Received Accepted Published The use of serological and virological tests has become essential in the management of hepatitis C virus HCV infection in order to diagnose infection guide treatment decisions and assess the virological response to antiviral therapy. Virological tools include serological assays for anti-HCV antibody detection and serological determination of the HCV genotype and molecular assays that detect and quantify HCV RNA and determine the HCV genotype. Anti-HCV antibody testing and HCV RNA testing are used to diagnose acute and chronic hepatitis C. Only patients with detectable HCV RNA should be considered for pegylated interferon alfa and ribavirin therapy and the HCV genotype should be systematically determined before treatment as it determines the indication the duration of treatment the dose of ribavirin and the virological monitoring procedure. HCV RNA monitoring during therapy is used to tailor treatment duration in HCV genotype 1 infection and molecular assays are used to assess the end-of-treatment and most importantly the sustained virological response . the endpoint of therapy. Key words Hepatitis C virus serological and virological tests HCV RNA 1. INTRODUCTION Virological testing has become essential in the management of hepatitis C virus

TỪ KHÓA LIÊN QUAN