tailieunhanh - Báo cáo y học: "Application of Small Angle X-ray Scattering (SAXS) for Differentiation between Normal and Cancerous Breast Tissue"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Application of Small Angle X-ray Scattering (SAXS) for Differentiation between Normal and Cancerous Breast Tissue. | Int. J. Med. Sci. 2005 2 118 Short research communication International Journal of Medical Sciences ISSN 1449-1907 2005 2 3 118-121 2005 Ivyspring International Publisher. All rights reserved Application of Small Angle X-ray Scattering SAXS for Differentiation between Normal and Cancerous Breast Tissue Vahid Changizi1 Mohammad A. Oghabian1 Robert Speller2 Saeed Sarkar1 Ali Arab Kheradmand1 1. Department of Medical Physics Faculty of Medicine Tehran University of Medical Sciences Research Center for Science Technology in Medicine Imam Khomaini Hospital Bolvare Keshavarz Tehran Iran 2. Department of Medical Physics and Bioengineering University College London Gower Street London WC1E 6BT UK Corresponding address Vahid Changizi. changizi@ Received Accepted Published Introduction Small angle between 3 and 10 X ray scattering is predominantly coherent giving rise to diffraction effects that can be observed as constructive and destructive interferences. These interferences carry information about the molecular structure of the tissue and hence can be used to identify changes that occur due to cancer. Method In this study an energy dispersive X-ray diffraction method was used. The optimum scattering angle determined from a series of measurements on adipose breast tissue at several angles from 4 to degrees was found to be . Once optimized the system was used to measure the diffraction profiles corrected scattered intensity versus momentum transfer of a total of 99 breast tissue samples. The samples were both normal and tumour samples. Results Adipose tissue showed a sharp high intensity peak at low momentum transfer values of approximately 1. Adipose tissue mixed tissue adipose fibroglandular and tumor have peaks at different values of momentum transfer that can be used to identify the tissue. Benign and malignant breast tissues can also be differentiated by both peak positions and peak heights.