tailieunhanh - Báo cáo y học: "Comparison of Classical and Clozapine Treatment on Schizophrenia Using Positive and Negative Syndrome Scale of Schizophrenia (PANSS) and SPECT Imaging"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Comparison of Classical and Clozapine Treatment on Schizophrenia Using Positive and Negative Syndrome Scale of Schizophrenia (PANSS) and SPECT Imaging. | Int. J. Med. Sci. 2005 2 79 Research paper Received Accepted Published Abstract Key words Author biography Corresponding address International Journal of Medical Sciences ISSN 1449-1907 2005 2 2 79-86 2005 Ivyspring International Publisher. All rights reserved Comparison of Classical and Clozapine Treatment on Schizophrenia Using Positive and Negative Syndrome Scale of Schizophrenia PANSS and SPECT Imaging Mohammad Sharafi 1 2 1. fMRI Research Center Columbia University New York NY USA 2. Department of Psychiatry and Nuclear Medicine Tehran Psychiatric Institute Iran University of Medical Sciences Tehran Iran Many neuroimaging studies of schizophrenia have shown abnormalities in the frontal cortex limbic system basal ganglia temporal and parietal lobes. These findings are not specific or consistent enough to build up a coherent theory of the origin of the brain abnormality in schizophrenia. This paper describes a state-of-the-art approach of SPECT to correlate neuropsychological evaluation. PANSS scores and different brain focal abnormalities of two groups of patients receiving Clozapine and classical antipsychotic treatments were observed. A total of 20 drug-free patients actively psychotic schizophrenic were selected according to the DSM-IV criteria. Pre-Post-treatment was designed using PANSS and 99mTc- ECD-SPECT to assess regional Cerebral Blood Flow rCBF . The results showed that after treatment differences in PANSS scores were significant in both groups with superior scores resulting from the Clozapine therapy. Results were supported by SPECT which showed a greater improvement in the Clozapine group. Both positive and negative symptoms were improved with Clozapine as well. Before treatment hypofrontality was the most common 85 finding whereas after treatment hypofrontality was mostly cleared. However in some areas like temporal and caudate hyperfrontality was induced. Negative symptoms showed linkage to .