tailieunhanh - Báo cáo y học: "A Practical Approach to Management of Chronic Hepatitis B"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: A Practical Approach to Management of Chronic Hepatitis B. | Int. J. Med. Sci. 2005 2 1 17 International Journal of Medical Sciences ISSN 1449-1907 2005 2 1 17-23 2005 Ivyspring International Publisher. All rights reserved Review Received Accepted Published A Practical Approach to Management of Chronic Hepatitis B Ke-Qin Hu Divisions of Gastroenterology and Transplantation University of California Irvine College of Medicine CA USA Abstract Chronic hepatitis B CHB is one of the important public health problems worldwide. Major advances have been made in the treatment of cHb during the past several years. This article systemically reviews advances in the application of HBV DNA quantitation and three approved drugs for HBV treatment and presents an updated and practical clinical approach to managing CHB. Highly sensitive PCR-based quantitation of HBV DNA makes it possible to precisely determine pre-treatment HBV load and monitor HBV DNA response during treatment. HBV DNA level HBeAg status degree of hepatic histological activity and fibrosis and serum transaminases are the most important parameters in determining indication regimen and duration of hBv treatment. Although interferon alfa-2b lamivudine and adefovir are all approved as initial HBV treatment understanding the advantages and advantages of each agent is important in choosing the best treatment for each individual patient with CHB. Key words Chronic Hepatitis B Management treatment Author Ke-Qin Hu MD is the Director of Hepatology Services and Associate Professor of Clinical biography Medicine Divisions of Gastroenterology and Transplantation University of California Irvine California USA. His current researches include natural history and management of hepatitis B and C and chemoprevention of hepatocellular carcinoma. Corresponding address Ke-Qin Hu MD Division of Gastroenterology University of California Irvine 101 The City DriveBuilding 53 Room 113 Orange CA 92868. Phone 714 456-6145 FAX 714 4567753 Email kqhu@