tailieunhanh - báo cáo hóa học:" Combination therapy: the next opportunity and challenge of medicine"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Combination therapy: the next opportunity and challenge of medicine | Ascierto and Marincola Journal of Translational Medicine 2011 9 115 http content 9 1 115 JOURNAL OF TRANSLATIONAL MEDICINE EDITORIAL Open Access Combination therapy the next opportunity and challenge of medicine Paolo A Ascierto 1 and Francesco M Marincola2 Abstract From an historical point of view combination therapy was the basis for the care of important diseases like infection diseases or cancer. Today the cocktail drug of the Highly Active Anti Retroviral Therapy HAART has reduced the death for HIV infection changing the outcome of such disease. Moreover the combination of different strategies changed the course of transplants both in haematology and surgical transplant . Different diseases with high social impact including cardiovascular metabolic obesity hypercholesterolaemia and diabetes and autoimmune diseases have better results with combinations of different drug classes of drugs. After recent successes in the immunotherapy field Sepuleucel-T ipilimumab and the new promising small molecule therapies cancer should be the next challenge for combination strategies. In order to accomplish these objectives open discussion and cooperation among companies academic and other institutions will be increasingly important. For all of these reasons we have created a new subsection of the Journal of Translational Medicine. Why should a Subsection of the Journal of Translational Medicine be dedicated to combination strategies Because we want to stimulate discussion over this hot topic. In recent years several compounds have been developed to treat a broad number of diseases targeting a specific mechanism. However vast majority of common diseases are multi-factorial and cannot realistically be controlled by targeting a single or few pathways. Tuberculosis treatment is a classic example of combination therapy 1 . After the discovery of Streptomycin in 1944 improvement in the effectiveness of therapy was observed with the addition of .