tailieunhanh - Báo cáo y học: "yrosine kinase – Role and significance in Cancer"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Tyrosine kinase – Role and significance in Cancer. | Int. J. Med. Sci. 2004 1 2 101-115 101 Review Received Accepted Published Abstract Key words Author biography Corresponding address International Journal of Medical Sciences ISSN 1449-1907 2004 1 2 101-115 2004 Ivyspring International Publisher. All rights reserved Tyrosine kinase - Role and significance in Cancer Manash K. Paul and Anup K. Mukhopadhyay Department of Biotechnology National Institute of Pharmaceutical Education and Research Sector-67 Nagar Mohali Punjab India-160062 Tyrosine kinases are important mediators of the signaling cascade determining key roles in diverse biological processes like growth differentiation metabolism and apoptosis in response to external and internal stimuli. Recent advances have implicated the role of tyrosine kinases in the pathophysiology of cancer. Though their activity is tightly regulated in normal cells they may acquire transforming functions due to mutation s overexpression and autocrine paracrine stimulation leading to malignancy. Constitutive oncogenic activation in cancer cells can be blocked by selective tyrosine kinase inhibitors and thus considered as a promising approach for innovative genome based therapeutics. The modes of oncogenic activation and the different approaches for tyrosine kinase inhibition like small molecule inhibitors monoclonal antibodies heat shock proteins immunoconjugates antisense and peptide drugs are reviewed in light of the important molecules. As angiogenesis is a major event in cancer growth and proliferation tyrosine kinase inhibitors as a target for anti-angiogenesis can be aptly applied as a new mode of cancer therapy. The review concludes with a discussion on the application of modern techniques and knowledge of the kinome as means to gear up the tyrosine kinase drug discovery process. Tyrosine kinase Cancer Oncogenic activation Inhibitor Drug discovery Anup K. Mukhopadhyay is an Associate Professor of the Department of .