tailieunhanh - báo cáo hóa học:" Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-g in patients with chronic heart failure"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-g in patients with chronic heart failure | Cappuzzello et al. Journal of Translational Medicine 2011 9 28 http content 9 1 28 TRANSLATIONAL MEDICINE RESEARCH Open Access Increase of plasma IL-9 and decrease of plasma IL-5 IL-7 and IFN-g in patients with chronic heart failure I -J I ir li d 1770 I Ir i1 t I I Pii if 2t K iolr-h ir tr ir iTi3 rCi liiHr i K iolillr t3 I Qilwociri4 Plo n rsỉ Ciotori5 Claudia Cappuzzello Luca DI VIto Roberta fVielci lioiina Guido MelIllo Lorena Silvestri Eleonora Cesareo 2 I 2 3 ft A z- -3 3 Filippo Crea Giovanna Liuzzo Antonio Facchiano Maurizio C Capogrossi Monica Napolitano Abstract Background Several cytokines are associated with the development and or progression of chronic heart failure CHF . Our aim was to look more closely at the cytokine networks involved in CHF and to assess whether disease etiology affects cytokine expression. The study population was comprised of a 69 patients with stable CHF New York Heart Association NYHA II IV classes secondary to ischaemic ICM and non ischaemic dilated NIDCM cardiomyopathy and b 16 control subjects. We analyzed and compared the plasma levels of 27 pro- and antiinflammatory mediators in the study population and assessed for any possible correlation with echocardiographic parameters and disease duration. Methods 27 cytokines and growth factors were analyzed in the plasma of ICM- n 42 and NIDCM n 27 NYHA class II-IV patients vs age- and gender-matched controls n 16 by a beadbased multiplex immunoassay. Statistical analysis was performed by ANOVA followed by Tukey post-hoc test for multiple comparison. Results Macrophage inflammatory protein MIP -ip Vascular endothelial growth factor VEGF interleukin IL -9 Monocyte chemotactic protein MCP -1 and IL-8 plasma levels were increased in both ICM and NIDCM groups vs controls. In contrast IL-7 IL-5 and Interferon IFN -g were decreased in both ICM and NIDCM groups as compared to controls. Plasma IL-6 and IL-1 b were increased in ICM and decreased in NIDCM vs .