tailieunhanh - báo cáo hóa học:" Hypoxia-induced down-regulation of microRNA449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Hypoxia-induced down-regulation of microRNA449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression | Muth et al. Journal of Translational Medicine 2011 9 24 http content 9 1 24 TRANSLATIONAL MEDICINE CORRECTION Open Access Hypoxia-induced down-regulation of microRNA-449a b impairs control over targeted SERPINE1 PAI-1 mRNA - a mechanism involved in SERPINE1 PAI-1 overexpression 1 1 2 1 1 Michaela Muth Kais Hussein Christoph Jacobi Hans Kreipe Oliver Bock Abstract After publication of our article 1 we realized the need for posting a correction note in order to prevent i overinterpretation of some results by the readers and ii concerns about potentially unintended misguidance by the authors. Correction Array-based gene expression analysis mRNA miRNA respectively was performed in 2 independent experiments resulting in 2 values for differentially expressed targets Figures one and three . The resulting error bars therefore appear symmetrical. In the published figures two four five and six data from 1 experiment . 2 measurements are shown likewise resulting in symmetrical error bars. These figures are based on data sets underlying version 1 of the submitted manuscript. Version 2 of the manuscript for publication should contain figures two four five and six figures 1 2 3 and 4 in this correction and the underlying data sets from 3 independent experiments with 2 measurements values per experiment. Unfortunately internal errors eventually have led to discrepancies between intended illustration of data sets and the published ones. We have now incorporated the valid figures and figure legends. The underlying data set is shown in the supplement of this correction note additional file 1 . The corrected figures five and six figures 3 and 4 here now need particular attention because a subtle interpretation is necessary. Correspondence institute of Pathology Hannover Medical School Carl-Neuberg-Strasse 1 30625 Hannover Germany Full list of author information is available at the end of the article When we transfected .

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