tailieunhanh - báo cáo hóa học:" Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review | Rao et al. Journal of Translational Medicine 2011 9 17 http content 9 1 17 TRANSLATIONAL MEDICINE RESEARCH Open Access Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer a meta-analysis and system review Benqiang Rao1 4 Minyan Han2 Lei Wang1 4 Xiaoyan Gao3 Jun Huang1 Meijin Huang1 Huanliang Liu4 Jianping Wang1 4 Abstract Background To evaluate the objective clinical outcomes of active specific immunotherapy ASI in advanced colorectal cancer advanced CRC and suspected minimal residual colorectal cancer suspected minimal residual CRC . Methods A search was conducted on Medline and Pub Med from January 1998 to January 2010 for original studies on ASI in colorectal cancer CRC . All articles included in this study were assessed with the application of predetermined selection criteria and were divided into two groups ASI in advanced CRC and ASI in suspected minimal residual CRC. For ASI in suspected minimal residual CRC a meta-analysis was executed with results regarding the overall survival OS and disease-free survival DFS . Regarding ASI in advanced colorectal cancer a system review was performed with clinical outcomes. Results 1375 colorectal carcinoma patients with minimal residual disease have been enrolled in Meta-analysis. A significantly improved OS and DFS was noted for suspected minimal residual CRC patients utilizing ASI For OS HR P For DFS HR P . For ASI in stage II suspected minimal residual CRC OS approached significance when compared with control HR P however the difference in DFS of ASI for the stage II suspected minimal residual CRC reached statistical significance HR P . For ASI in stage III suspected minimal residual CRC compared with control The difference in both OS and DFS achieved statistical significance For OS HR P For DFS HR P . 656 advanced colorectal patients have been .