tailieunhanh - Báo cáo y học: "Association Study of Aromatase Gene (CYP19A1) in Essential Hypertension"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Association Study of Aromatase Gene (CYP19A1) in Essential Hypertension. | Int. J. Med. Sci. 2008 5 29 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2008 5 1 29-35 Ivyspring International Publisher. All rights reserved Association Study of Aromatase Gene CYP19A1 in Essential Hypertension Masanori Shimodaira1 Tomohiro Nakayama2 Naoyuki Sato3 Kosuke Saito2 4 Akihiko Morita5 Ichiro Sato6 Teruyuki Takahashi7 Masayoshi Soma8 Yoichi Izumi8 1. MD Program Nihon University School of Medicine Tokyo Japan 2. Division of Receptor Biology Advanced Medical Research Center Tokyo Japan 3. Division of Genomic Epidemiology and Clinical Trials Advanced Medical Research Center Tokyo Japan 4. Department of Applied Chemistry Toyo University School of Engineering Tokyo Japan 5. Department of Neurology Division of Neurology Department of Medicine Nihon University School of Medicine Tokyo Japan 6. Department of Obstetrics and Gynecology Nihon University School of Medicine Tokyo Japan 7. Department of Neurology Graduate School of Medicine Nihon University Tokyo Japan 8. Division of Nephrology and Endocrinology Department of Medicine Nihon University School of Medicine Tokyo Japan Correspondence to Tomohiro Nakayama MD Division of Receptor Biology Advanced Medical Research Center Nihon University School of Medicine Ooyaguchi-kamimachi 30-1 Itabashi-ku Tokyo 173-8610 Japan. Tel 81 3-3972-8111 Fax 81 3-5375-8076 E-mail tnakayam@ Received Accepted Published Background As aromatase-deficient mice which are deficient in estrogens reportedly have reduced blood pressure the aromatase gene CYP19A1 is thought to be a susceptibility gene for essential hypertension EH . The aim of the present study was to investigate the relationship between CYP19A1 and EH by examining single nucleotide polymorphisms SNPs . Methods Five SNPs in the human CYP19A1 gene rs1870049 rs936306 rs700518 rs10046 and rs4646 were selected and an association study was performed in 218 Japanese EH patients .