tailieunhanh - Báo cáo y học: "Do tonic and burst TMS modulate the lemniscal and extralemniscal system differentially"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Do tonic and burst TMS modulate the lemniscal and extralemniscal system differentially? | Int. J. Med. Sci. 2007 4 242 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2007 4 5 242-246 Ivyspring International Publisher. All rights reserved Do tonic and burst TMS modulate the lemniscal and extralemniscal system differentially Dirk De Ridder 1 Elsa van der Loo 1 Karolien Van der Kelen 1 Tomas Menovsky 1 Paul van de Heyning 1 Aage Moller 2 1. Dept of Neurosurgery and ENT University Hospital Antwerp Belgium 2. School of Behavioral and Brain Science University of Texas at Dallas Dallas USA Correspondence to Dirk De Ridder Dept of Neurosurgery University Hospital Antwerp Wilrijkstraat 10 2650 Edegem Belgium. Tel 32 3 8213336 Fax 32 3 8252428 Received Accepted Published Introduction Tinnitus is an auditory phantom percept related to tonic and burst hyperactivity of the auditory system. Two parallel pathways supply auditory information to the cerebral cortex the tonotopically organised lemniscal system and the non-tonotopic extralemniscal system firing in tonic mode and burst mode respectively. Transcranial magnetic stimulation TMS is a non-invasive method capable of modulating activity of the human cortex by delivering tonic or burst stimuli. Burst stimulation is shown to be more powerful in activating the cerebral cortex than tonic stimulation and bursts may activate neurons that are not activated by tonic stimulations. Methods The effect of both tonic and burst TMS in 14 placebo-negative patients presenting narrow band white noise tinnitus were analysed. Results Our TMS results show that narrow band white noise tinnitus is better suppressed with burst TMS in comparison to tonic TMS f 13 p .000. For pure tone tinnitus no difference is found between burst or tonic TMs f 13 .3 ns. Discussion Based on the hypothesis that white noise is the result of hyperactivity in the non-tonotopic system and pure tone tinnitus of the tonotopic system we suggest that burst