tailieunhanh - Báo cáo y học: "Hypoalbuminaemia – A Marker of Cardiovascular Disease in Patients with Chronic Kidney Disease Stages II - IV"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Hypoalbuminaemia – A Marker of Cardiovascular Disease in Patients with Chronic Kidney Disease Stages II - IV. | Int. J. Med. Sci. 2008 5 366 International Journal of Medical Sciences ISSN 1449-1907 2008 5 6 366-370 Ivyspring International Publisher. All rights reserved Research Paper Hypoalbuminaemia - A Marker of Cardiovascular Disease in Patients with Chronic Kidney Disease Stages II - IV Nehal Rachit Shah1 H and Francis Dumler2 1. Division of Internal Medicine St Joseph Mercy Oakland Pontiac MI USA 2. Division of Nephrology William Beaumont Hospital Royal Oak MI USA H Correspondence to Nehal Shah MD 727 Woodlawn Ave Royal Oak MI 48073. Email drshahnehal@ Received Accepted Published Cardiovascular disease CVD is a major cause of morbidity and mortality in patients with chronic kidney disease CKD patients. Serum albumin a negative acute-phase reactant and marker for underlying inflammation and or malnutrition is an independent predictor of CVD and mortality in CKD VI patients. Such an association in patients with less severe CKD is not well established. We conducted a cross sectional study of all CKD II - IV patients attending the nephrology clinic N 376 mean age 57 17 years GFR 47 20 mL min females 48 blacks 15 diabetics 27 hypertensive 79 . Laboratory and clinical data including risk factors and evidence of CVD were obtained at the point of the most recent visit. The association between risk factors and CVD was evaluated by logistic regression. In the simple logistic regression model age p sex P hypertension P diabetes P .0001 dyslipidemia p .01 and serum albumin p .0001 were found to be statistically significant. Serum albumin was found to be an independent predictor p of CVD by multiple logistic regression analysis using the above risk factor variables. In conclusion a hypoalbuminaemia is an independent predictor of CVD in early CKD stages b hypoalbu-minaemia may be used to identify the population at higher risk for CVD. Key words Hypoalbuminaemia cardiovascular disease chronic .