tailieunhanh - Báo cáo y học: " Eph Receptors and Ephrin Signaling"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Eph Receptors and Ephrin Signaling . | Int. J. Med. Sci. 2008 5 263 International Journal of Medical Sciences ISSN 1449-1907 2008 5 5 263-272 Ivyspring International Publisher. All rights reserved Review Eph Receptors and Ephrin Signaling Pathways A Role in Bone Homeostasis Claire M. Edwards3 Gregory R. Mundy Vanderbilt Center for Bone Biology Departments of Cancer Biology and Clinical Pharmacology Medicine Vanderbilt University Nashville TN USA. H Correspondence to Claire M. Edwards Vanderbilt Center for Bone Biology 2215 Garland Avenue Room 1235 Vanderbilt University Nashville TN 37232-0575. Phone 615 343 2801 Fax 615 343 2611 Email Received Accepted Published The maintenance of bone homeostasis is tightly controlled and largely dependent upon cellular communication between osteoclasts and osteoblasts and the coupling of bone resorption to bone formation. This tight coupling is essential for the correct function and maintenance of the skeletal system repairing microscopic skeletal damage and replacing aged bone. A range of pathologic diseases including osteoporosis and cancer-induced bone disease disrupt this coupling and cause subsequent alterations in bone homeostasis. Eph receptors and their associated ligands ephrins play critical roles in a number of cellular processes including immune regulation neuronal development and cancer metastasis. Eph receptors are also expressed by cells found within the bone marrow microenvironment including osteoclasts and osteoblasts and there is increasing evidence to implicate this family of receptors in the control of normal and pathological bone remodeling. Key words Bone remodeling Eph receptors ephrins coupling osteoblast osteoclast INTRODUCTION The maintenance of bone homeostasis is essential for the correct function of the skeleton including skeletal growth repair of skeletal damage and replacement of aged bone. Bone remodeling is a continual process and the coupling of bone .