tailieunhanh - Báo cáo toán học: "Of rodents and humans: a light microscopic and ultrastructural study on cardiomyocytes in pulmonary veins"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Of rodents and humans: a light microscopic and ultrastructural study on cardiomyocytes in pulmonary veins. | Int. J. Med. Sci. 2008 5 152 Research Paper International Journal of Medical Sciences ISSN 1449-1907 2008 5 3 152-158 Ivyspring International Publisher. All rights reserved Of rodents and humans a light microscopic and ultrastructural study on cardiomyocytes in pulmonary veins Josef Mueller-Hoecker1 Frigga Beitinger1 Borja Fernandez2 Olaf Bahlmann1 Gerald Assmann1 Christian Troidl3 Ilias Dimomeletis4 Stefan Kaab4 Elisabeth Deindl5 1. Institute of Pathology Ludwig-Maximillians-University Munich Germany 2. Faculty of Science University of Malaga Spain 3. Kerckhoff Klinik Bad Nauheim Germany 4. Klinikum Grosshadern Ludwig-Maximillians-University Munich Germany 5. Walter-Brendel-Centre of Exp. Medicine Ludwig-Maximillians-University Munich Germany Correspondence to Elisabeth Deindl PhD Walter-Brendel-Centre of Exp. Medicine Ludwig-Maximillians-University Munich Marchioninistr. 27 D-81377 Munchen Germany. e-mail Phone 49 89 2180-76504 Fax 49 89 2180-76503 Received Accepted Published Cardiomyocytes in pulmonary veins PVs have been reported in rodents and humans. In humans they were related to atrial arrhythmias including atrial fibrillation AF . To investigate histological similarities and differences in PV cardiomyocyte localization and distribution we performed comparative light and electron microscopic studies on humans rats and mice and generated a transgenic mouse strain. Results on mice C57BL 6 and BALBc and rats Wistar revealed that cardiomyocytes regularly extend from the hilus along venous vessels into the lung tissue surrounding individual intrapulmonary veins of varying diameters 70-250pm . The cardiomyocytes showed the ultrastructure of a normal working myocardium with intact intercalated discs and tightly packed contractile filaments. In both lung and hilus cardiomyocytes were localized either close to the basal lamina of the endothelium or separated from it by smooth muscle