tailieunhanh - Báo cáo hóa học: " Correlating novel variable and conserved motifs in the Hemagglutinin protein with significant biological functions"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Correlating novel variable and conserved motifs in the Hemagglutinin protein with significant biological functions | Virology Journal BioMed Central Open Access Correlating novel variable and conserved motifs in the Hemagglutinin protein with significant biological functions Deena MA Gendoo1 Mahmoud M El-Hefnawi3 Mark Werner4 and Rania Siam 1 2 Address 1YJ-Science and Technology Research Center STRC American University in Cairo Cairo Egypt - Department of Biology American University in Cairo Cairo Egypt 3Department of Informatics and Systems Division of Engineering Sciences Research National Research Centre NRC Cairo Egypt and 4Department of Mathematics and Actuarial Science American University in Cairo Cairo Egypt Email Deena MA Gendoo - deena_gendoo@ Mahmoud M El-Hefnawi - mahef@ Mark Werner - mwerner@ Rania Siam - rsiam@ Corresponding author Published 5 August 2008 Received 29 June 2008 Accepted 5 August 2008 Virologyjournal 2008 5 91 doi 186 1743-422X-5-91 This article is available from http content 5 1 91 2008 Gendoo et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Variations in the influenza Hemagglutinin protein contributes to antigenic drift resulting in decreased efficiency of seasonal influenza vaccines and escape from host immune response. We performed an in silico study to determine characteristics of novel variable and conserved motifs in the Hemagglutinin protein from previously reported H3N2 strains isolated from Hong Kong from 1968-1999 to predict viral motifs involved in significant biological functions. Results 14 MEME blocks were generated and comparative analysis of the MEME blocks identified blocks 1 2 3 and 7 to correlate with several biological functions. Analysis of the different Hemagglutinin sequences elucidated that the .