tailieunhanh - Báo cáo hóa học: " Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses | Virology Journal BioMed Central Research Heavily glycosylated highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses Dawnnica Eastman1 2 Anne Piantadosi1 3 Xueling Wu1 6 Donald N Forthal4 Gary Landucci4 Jason T Kimata5 and Julie Overbaugh 1 3 Address division of Human Biology Fred Hutchinson Cancer Research Center Seattle WA USA 2Program in Molecular and Cellular Biology University of Washington Seattle WA USA 3Department of Pathobiology University of Washington Seattle WA USA 4Division of Infectious Diseases University of California Irvine CA USA 5Molecular Virology and Microbiology Baylor College of Medicine Houston TX USA and 6Vaccine Research Center NIAID NIH Bethesda MD USA Email Dawnnica Eastman - dke2002@ Anne Piantadosi - apiantad@ Xueling Wu - wuxue@ Donald N Forthal - dnfortha@ Gary Landucci - glanducc@ Jason T Kimata - jkimata@ Julie Overbaugh - joverbau@ Corresponding author Open Access Published 4 August 2008 Received 26 June 2008 Virology Journal 2008 5 90 doi 1743-422X-5-90 Accepted 4 August 2008 This article is available from http content 5 1 90 2008 Eastman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lentiviruses such as human and simian immunodeficiency viruses HIV and SIV undergo continual evolution in the host. Previous studies showed that the late-stage variants of SIV that evolve in one host replicate to significantly higher levels when transmitted to a new host. However it is unknown whether HIVs or SIVs that have higher .

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