tailieunhanh - Báo cáo hóa học: " The synergistic effect of IFN-α and IFN-γ against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The synergistic effect of IFN-α and IFN-γ against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin | Virology Journal BioMed Central Research The synergistic effect of IFN-a and IFN-Y against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3 11-dihydroxymeliacarpin Erina Petrera and Celia E Coto Open Access Address Laboratory of Virology Department of Biochemistry School of Science University of Buenos Aires Buenos Aires Argentina Email Erina Petrera - epetrera@ Celia E Coto - virocoto@ Corresponding author Published 13 June 2006 Received 06 March 2006 Accepted 13 June 2006 Virology Journal 2006 3 45 doi l 743-422X-3-45 This article is available from http content 3 1 45 2006 Petrera and Coto licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent studies have shown that gamma interferon IFN-y synergizes with IFN-a p to inhibit herpes simplex virus type 1 HSV-1 replication in vitro. Since IFN response represents an early host defense event against viral infection and the fact that treatment with meliacine a plant antiviral ameliorate the severity of the herpetic infection in female mice infected intravaginally with HSV-2 we wanted to investigate whether the administration of meliacine to HSV-2 infected mice could altered the homoestasis of IFNs host response. For this purpose we studied the effect of the compound 1-cinnamoyl-3 11-dihydroxymeliacarpin CDM which is the responsible for meliacine antiviral action on the HSV-2 inhibition exerted by IFN a IFN-y or their combination. Results We have found that like HSV-1 IFN-y synergizes with IFN-a to inhibit HSV-2 replication in Vero cells. While treatment with IFN-a or IFN-y alone has weak antiviral action HSV-2 plaque formation viral replication and the onset of viral .

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