tailieunhanh - Báo cáo hóa học: " Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized mice"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized mice | Virology Journal BioMed Central Research Open Access Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized mice Rajeswari Singam Prasanna K Jena Sumita Behera Gary R Hellermann Richard F Lockey Dennis Ledford and Shyam S Mohapatra Address Division of Allergy and Immunology Joy McCann Culverhouse Airway Disease Research Center University of South Florida College of Medicine and James A. Haley VA Hospital Tampa FL USA Email Rajeswari Singam - rsingam@ Prasanna K Jena - jprasann@ Sumita Behera - sbehera@ Gary R Hellermann - ghellerm@ Richard F Lockey - rlockey@ Dennis Ledford - dledford@ Shyam S Mohapatra - smohapat@ Corresponding author Published 23 May 2006 Received 15 February 2006 Accepted 23 May 2006 Virology Journal 2006 3 32 doi I86 I743-422X-3-32 This article is available from http content 3 1 32 2006 Singam et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Respiratory syncytial virus RSV infection is the major cause of bronchiolitis in infants and is a risk factor for the development of asthma. Allergic asthmatics are more susceptible to RSV infection and viral exacerbation. Methods Since the effectiveness of corticosteroids in treating RSV infection has been controversial we tested fluticasone propionate FP and salmeterol Sal alone versus FP plus Sal FPS on RSV-induced airway inflammation. Mice were sensitized and challenged with ovalbumin OVA and infected with RSV. Following infection they were treated with FP Sal or FPS intranasally and airway hyperreactivity AHR inflammation and RSV titers were examined. Results