tailieunhanh - Báo cáo hóa học: " Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection | Virology Journal BioMed Central Research Open Access Expression of HIV receptors alternate receptors and co-receptors on tonsillar epithelium implications for HIV binding and primary oral infection Renu B Kumar1 2 Diane M Maher1 Mark C Herzberg2 and Peter J Southern 1 Address department of Microbiology University of Minnesota Minneapolis MN 55455 USA and department of Diagnostic and Biological Sciences and the Mucosal and Vaccine Research Center University of Minnesota Minneapolis MN 55455 USA Email Renu B Kumar - rkumar@ Diane M Maher - dmaher@ Mark C Herzberg - mcherzb@ Peter J Southern - peter@ Corresponding author Published 06 April 2006 Received 04 October 2005 Accepted 06 April 2006 Virology Journal2006 3 25 doi 1743-422X-3-25 This article is available from http content 3 1 25 2006Kumar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Primary HIV infection can develop from exposure to HIV in the oral cavity. In previous studies we have documented rapid and extensive binding of HIV virions in seminal plasma to intact mucosal surfaces of the palatine tonsil and also found that virions readily penetrated beneath the tissue surfaces. As one approach to understand the molecular interactions that support HIV virion binding to human mucosal surfaces we have examined the distribution of the primary HIV receptor CD4 the alternate HIV receptors heparan sulfate proteoglycan HS and galactosyl ceramide GalCer and the co-receptors CXCR4 and CCR5 in palatine tonsil. Results Only HS was widely expressed on the surface of stratified squamous epithelium. In contrast HS GalCer CXCR4 and CCR5 were all expressed on the reticulated epithelium .