tailieunhanh - Báo cáo hóa học: " Predicting the subcellular localization of viral proteins within a mammalian host cell"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Predicting the subcellular localization of viral proteins within a mammalian host cell | Virology Journal BioMed Central Research Open Access Predicting the subcellular localization of viral proteins within a mammalian host cell MS Scott1 R Oomen2 DY Thomas3 and MT Hallett 1 Address 1McGill Center for Bioinformatics McGill University 3775 University Street Montreal Quebec Canada integrated Genomics Sanofi Pasteur 1755 Steeles Avenue West Toronto Ontario Canada and 3Biochemistry Department McGill University McIntyre Medical Sciences Building 3655 Promenade Sir William Osler Montreal Quebec Canada Email MS Scott - R Oomen - DY Thomas - MT Hallett - hallett@ Corresponding author Published 04 April 2006 Received 22 December 2005 Accepted 04 April 2006 Virology Journal 2006 3 24 doi l 743-422X-3-24 This article is available from http content 3 1 24 2006 Scott et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The bioinformatic prediction of protein subcellular localization has been extensively studied for prokaryotic and eukaryotic organisms. However this is not the case for viruses whose proteins are often involved in extensive interactions at various subcellular localizations with host proteins. Results Here we investigate the extent of utilization of human cellular localization mechanisms by viral proteins and we demonstrate that appropriate eukaryotic subcellular localization predictors can be used to predict viral protein localization within the host cell. Conclusion Such predictions provide a method to rapidly annotate viral proteomes with subcellular localization information. They are likely to have widespread applications both in the study of the functions of viral .