tailieunhanh - Báo cáo hóa học: " Homologous recombination is unlikely to play a major role in influenza B virus evolution"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Homologous recombination is unlikely to play a major role in influenza B virus evolution | Virology Journal BioMed Central Short report Open Access Homologous recombination is unlikely to play a major role in influenza B virus evolution Guan-Zhu Han 11 2 Xi-Ping Liu12 and Si-Shen Li 1 Address 1National Key Laboratory of Crop Biology College of Agronomy Shandong Agricultural University Tai an 271018 China and 2College of Life Science Shandong Normal University Jinan 250014 China Email Guan-Zhu Han - hanguanzhu@ Xi-Ping Liu - lixiping1988@ Si-Shen Li - ssli@ Corresponding authors fEqual contributors Published 27 May 2008 Received 10 April 2008 Accepted 27 May 2008 Virology journal 2008 5 65 doi 1743-422X-5-65 This article is available from http content 5 1 65 2008 Han et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Influenza B viruses cause a significant amount of morbidity and mortality. The occurrence of homologous recombination in influenza viruses is controversial. To determine the extent of homologous recombination in influenza B viruses recombination analyses of 2 650 sequences representing all eight segments of the influenza B viruses were carried out. Only four sequences were indentified as putative recombinants which were verified using phylogenetic methods. However the mosaics detected here were much likely to represent cases of laboratory-generated artificial recombinants. As in other myxoviruses it is unlikely that homologous recombination plays a major role in influenza B virus evolution. Background Influenza B viruses cause substantial morbidity and mortality in humans. As a member of the Orthomyxoviridae family influenza B virus possesses a .