tailieunhanh - Báo cáo hóa học: " Closing two doors of viral entry: Intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Closing two doors of viral entry: Intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1 | Virology Journal BioMed Central Open Access Closing two doors of viral entry Intramolecular combination of a coreceptor- and fusion inhibitor of HIV-1 Erhard Kopetzki11 Andreas Jeklet2 Changhua Ji2 Eileen Rao2 Jun Zhang2 Stephan Fischer1 Nick Cammack2 Surya Sankuratri 2 and Gabrielle Heilek2 Address Pharmaceuticals Division Roche Penzberg Penzberg Germany and 2Virology Diseases Area Roche Palo Alto 3431 Hillview Ave. Palo Alto CA USA Email Erhard Kopetzki - Andreas Jekle - Changhua Ji - Eileen Rao - Jun Zhang - Stephan Fischer - Nick Cammack - Surya Sankuratri - Gabrielle Heilek - Corresponding author tEqual contributors Published I May 2008 Received 25 March 2008 Accepted 1 May 2008 Virology journal 2008 5 56 doi 1743-422X-5-56 This article is available from http content 5 1 56 2008 Kopetzki et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ We describe a novel strategy in which two inhibitors of HIV viral entry were incorporated into a single molecule. This bifunctional fusion inhibitor consists of an antibody blocking the binding of HIV to its co-receptor CCR5 and a covalently linked peptide which blocks envelope mediated viruscell fusion. This novel bifunctional molecule is highly active on CCR5- and X4-tropic viruses in a single cycle assay and a reporter cell line with IC50 values of nM. We demonstrated that both inhibitors contribute to the antiviral activity. In the .

TÀI LIỆU LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.