tailieunhanh - Báo cáo hóa học: " The herpesvirus 8 encoded chemokines vCCL2 (vMIP-II) and vCCL3 (vMIP-III) target the human but not the murine lymphotactin receptor"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The herpesvirus 8 encoded chemokines vCCL2 (vMIP-II) and vCCL3 (vMIP-III) target the human but not the murine lymphotactin receptor | Virology Journal BioMed Central Research The herpesvirus 8 encoded chemokines vCCL2 vMIP-II and vCCL3 vMIP-III target the human but not the murine lymphotactin receptor Hans R Luttichau1 2 Address laboratory for Molecular Pharmacology Department of Neuroscience and Pharmacology Panum Institute DK-2200 Copenhagen Denmark and 2Department for Infectious Diseases Hvidovre Hospital Copenhagen Denmark Email Hans R Luttichau - LUTTICHAU@ Open Access Published 21 April 2008 Received 16 November 2007 Accepted 21 April 2008 Virology journal 2008 5 50 doi 1743-422X-5-50 This article is available from http content 5 1 50 2008 Luttichau licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Large DNA-viruses such as herpesvirus and poxvirus encode proteins that target and exploit the chemokine system of their host. The Kaposi sarcoma- associated herpes virus KSHV encodes three chemokines. Two of these vCCL2 and vCCL3 target the human lymphotactin receptor as an antagonist and a selective agonist respectively. Therefore these virally endcoded chemokines have the potential to be used as tools in the study of lymphotactin receptor pathways in murine models. Results The activities of vCCL2 vCCL3 human lymphotactin XCL1 and murine lymphotactin mXCL1 were probed in parallel on the human and murine lymphotactin receptor XCR1 and mXCR1 using a phosphatidyl-inositol assay. On the human XCR1 vCCL3 mXCL1 and XCL1 acted as agonists. In contrast only mXCL1 was able to activate the murine lymphotactin receptor. Using the same assay vCCL2 was able to block the response using any of the three agonists on the humane .