tailieunhanh - Báo cáo hóa học: " Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review | Virology Journal BioMed Central Review Open Access Severe cytomegalovirus infection in apparently immunocompetent patients a systematic review Petros I Rafailidis1 2 Eleni G Mourtzoukou1 loannis C Varbobitis1 and Matthew E Falagas 1 2 3 Address 1Alfa Institute of Biomedical Sciences AIBS Athens Greece 2Department of Medicine Henry Dunant Hospital Athens Greece and 3Department of Medicine Tufts University School of Medicine Boston Massachusetts USA Email Petros I Rafailidis - Eleni G Mourtzoukou - loannis C Varbobitis - Matthew E Falagas - Corresponding author Published 27 March 2008 Virology Journal 2008 5 47 doi 1743-422X-5-47 Received 5 March 2008 Accepted 27 March 2008 This article is available from http content 5 1 47 2008 Rafailidis et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The morbidity and mortality associated with cytomegalovirus CMV infection in immunocompromised patients especially in HIV-infected patients and transplant recipients as well as with congenital CMV infection are well known. In contrast relatively little attention has been paid to the morbidity and mortality that CMV infection may cause in immunocompetent patients. Methods We reviewed the evidence associated with severe manifestations of CMV infection in apparently immunocompetent patients and the potential role of antiviral treatment for these infections. We searched in PubMed Scopus and the Cochrane Library for the period of 1950-2007 to identify relevant articles. Results We retrieved 89 articles reporting on severe CMV infection in 290 immunocompetent adults. Among these reports the gastrointestinal .