tailieunhanh - Báo cáo hóa học: " Connective tissue metabolism in chikungunya patients"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Connective tissue metabolism in chikungunya patients | Virology Journal BioMed Central Open Access Connective tissue metabolism in chikungunya patients Sudarsanareddy Lokireddy1 Sarojamma Vemula2 and Ramakrishna Vadde 1 Address Department of Biotechnology Sri Krishnadevaraya University Anantapur India and 2Department of Community Medicine Government Medical College Anantapur India Email Sudarsanareddy Lokireddy - l_suda2003@ Sarojamma Vemula - vemula_saroja@ Ramakrishna Vadde - krishnavr2007@ Corresponding author Published 27 February 2008 Received 16 January 2008 Accepted 27 February 2008 Virology journal 2008 5 31 doi l743-422X-5-3l This article is available from http content 5 l 3l 2008 Lokireddy et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Chikungunya CHIK fever is a viral disease transmitted to humans by the bite of Chikungunya virus CHIK virus infected Aedes mosquitoes. CHIK virus is a member of the Alphavirus genus of the family Togaviridae. Previous reports have indicated that infection with CHIK virus produces an acute arthritis in human hosts by large area of necrosis and collagenosis or fibrosis. Results We carried out the present study to determine the effect of chikungunya on the collagen and connective tissue metabolism in 75 chikungunya-affected people. First we screened for mucopolysaccharides in urine by Cetyl Trimethyl Ammonium Bromide CTAB test. Appearance of heavy precipitate indicates the presence of higher levels of mucopolysaccharides and later quantified by DMB dye method. The urinary mucopolysaccharide in CHIK patients was 342 45 mg l compared to healthy controls 45 mg l . The collagen building blocks proline and hydroxyproline were also measured in CHIK .