tailieunhanh - Báo cáo hóa học: " Down-regulation of cell surface CXCR4 by HIV-1"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Down-regulation of cell surface CXCR4 by HIV-1 | Virology Journal BioMed Central Open Access Down-regulation of cell surface CXCR4 by HIV-1 Bongkun Choi 1 4 Paul J Gatti1 5 Cesar D Fermin2 Sandor Vigh3 Allyson M Haislip1 and Robert F Garry1 Address Department of Microbiology and Immunology Tulane University Health Sciences Center New Orleans LA 70112 USA 2College of Veterinary Medicine Nursing Allied Health CVMNAH Tuskegee University Tuskegee AL 36088 USA 3Department of Structural Cellular Biology Tulane University Health Sciences Center New Orleans LA 70112 USA 4Departments of Environmental Medicine Pathology and Medicine New York University School of Medicine Tuxedo NY 10987 USA and 5Biocompare Inc. 395 Oyster Point Blvd South San Francisco CA 94080 USA Email Bongkun Choi - choib01@ Paul J Gatti - pgatti@ Cesar D Fermin - fermin_c@ Sandor Vigh - svigh@ Allyson M Haislip - amh777@ Robert F Garry-rfgarry@ Corresponding author Published II January 2008 Received 21 December 2007 Accepted 1 1 January 2008 Virology Journal 2008 5 6 doi 1743-422X-5-6 This article is available from http content 5 1 6 2008 Choi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background CXC chemokine receptor 4 CXCR4 a member of the G-protein-coupled chemokine receptor family can serve as a co-receptor along with CD4 for entry into the cell of T-cell tropic X4 human immunodeficiency virus type 1 HIV-1 strains. Productive infection of T-lymphoblastoid cells by X4 HIV-1 markedly reduces cell-surface expression of CD4 but whether or not the co-receptor CXCR4 is down-regulated has not been conclusively determined. Results Infection of human T-lymphoblastoid cell line RH9 with HIV-1 resulted in