tailieunhanh - Báo cáo hóa học: " Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade | Virology Journal BioMed Central Research Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf MEK ERK signal cascade Henju Marjuki1 Hui-Ling Yen1 John Franks1 Robert G Webster 1 2 Stephan Pleschka3 and Erich Hoffmann1 Address 1Division of Virology Department of Infectious Diseases St. Jude Children s Research Hospital Memphis TN 38105 USA 2Department of Pathology University of Tennessee Memphis TN 38105 USA and Institute for Medical Virology Justus-Liebig University Giefien 35392 Germany Email Henju Marjuki - Hui-Ling Yen - John Franks - Robert G Webster - Stephan Pleschka - Erich Hoffmann - Corresponding author Open Access Published 5 December 2007 Received 15 November 2007 Accepted 5 December 2007 Virology Journal 2007 4 134 doi l743-422X-4-l34 This article is available from http content 4 l l34 2007 Marjuki et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Influenza viruses replicate within the nucleus of infected cells. Viral genomic RNA three polymerase subunits PB2 PBl and PA and the nucleoprotein NP form ribonucleoprotein complexes RNPs that are exported from the nucleus late during the infectious cycle. The virus-induced Raf MEK ERK MAPK signal cascade is crucial for efficient virus replication. Blockade of this pathway retards RNP export and reduces virus titers. Hemagglutinin HA accumulation and its tight association with lipid rafts activate ERK and enhance .